Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario M4N 3M5, Canada.
Expert Rev Pharmacoecon Outcomes Res. 2014 Feb;14(1):139-46. doi: 10.1586/14737167.2014.864560. Epub 2013 Dec 10.
To identify which domains/symptoms from the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) were predictive of overall quality of life (QoL) in advanced cancer patients.
Four hundred and forty seven patients with brain metastases or bone metastases from seven countries were enrolled with regression analysis to determine the predictive value of the QLQ-C30 functional/symptom scores for patient reported overall QoL (question 30), overall health (question 29) and the global health status domain (questions 29 and 30).
Worse role functioning, social functioning, fatigue and financial problems were the most significant predictive factors for worse QoL. In the bone metastases subgroup (n = 400), role functioning, fatigue and financial problems were the most significant predictors. In patients with brain metastases (n = 47), none of the EORTC domains significantly predicted worse QOL.
Deterioration of certain QLQ-C30 functional/symptom scores significantly contributes to worse QoL, overall health and global health status.
确定欧洲癌症研究与治疗组织生存质量问卷核心 30 问卷（EORTC QLQ-C30）的哪些领域/症状与晚期癌症患者的整体生存质量（QoL）相关。
从 7 个国家的 447 名脑转移或骨转移患者中进行回归分析，以确定 QLQ-C30 功能/症状评分对患者报告的整体 QoL（问题 30）、整体健康（问题 29）和全球健康状况领域（问题 29 和 30）的预测价值。
较差的角色功能、社会功能、乏力和经济问题是 QoL 较差的最显著预测因素。在骨转移亚组（n=400）中，角色功能、乏力和经济问题是最重要的预测因素。在脑转移患者中（n=47），EORTC 各领域均未显著预测 QOL 较差。
QLQ-C30 某些功能/症状评分的恶化显著导致 QoL、整体健康和全球健康状况的恶化。
