Microbiology Laboratory, The First People's Hospital of Lian Yun Gang, 182 North Tongguan Road, Xinpu 222002, China.
Microbiology Laboratory, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China.
Int J Biol Macromol. 2014 Mar;64:137-8. doi: 10.1016/j.ijbiomac.2013.12.001. Epub 2013 Dec 8.
The fruit of pumpkin (Cucurbita moschata) is one of the most important vegetables in the world. This study was conducted to investigate the hypolipidemic effect of the polysaccharide isolated from pumpkin (PP). Male Sprague-Dawley rats were divided into three groups and treated with diets containing either high fat, PP, or normal fat. Oral administration of PP could significantly decrease the levels of plasma triacylglycerol (TG), total cholesterol (TC), and plasma low-density lipoprotein cholesterol and increase the levels of fecal fat, cholesterol, and plasma high-density lipoprotein cholesterol. Therefore, results suggest that PP had a high hypolipidemic activity and could be explored as a possible agent for hyperlipidemia.
南瓜（Cucurbita moschata）果实是世界上最重要的蔬菜之一。本研究旨在探讨从南瓜中分离得到的多糖（PP）的降血脂作用。雄性 Sprague-Dawley 大鼠分为三组，分别用含有高脂肪、PP 或正常脂肪的饮食喂养。PP 的口服给药可显著降低血浆三酰甘油（TG）、总胆固醇（TC）和血浆低密度脂蛋白胆固醇水平，增加粪便脂肪、胆固醇和血浆高密度脂蛋白胆固醇水平。因此，结果表明 PP 具有很高的降血脂活性，可作为治疗高血脂的潜在药物。
