Wu Shengjun, Lu Mingsheng, Wang Shujun
College of Marine Life and Fisheries, Huaihai Institute of Technology, 59 Cangwu Road, Haizhou, Lianyungang, 222005, China.
Marine Resources Development Institute of Jiangsu, Huaihai Institute of Technology, 59 Cangwu Road, Haizhou, Lianyungang, 222005, China.
3 Biotech. 2017 Jul;7(3):166. doi: 10.1007/s13205-017-0852-0. Epub 2017 Jun 29.
Hyperglycaemia and hyperlipidaemia are major risk factors for coronary artery diseases and atherosclerosis. Peach gum polysaccharides (PGPs) possess various bioactivities. In this study, PGPs were extracted with thermostable α-amylase and investigated in terms of hypolipidaemic and hypoglycaemic activities. KKAy mice were gavaged once daily with either PGPs or distilled water (control group) for 3 weeks. Oral administration of PGPs decreased the levels of serum triglyceride, cholesterol low-density lipoprotein cholesterol, fasting blood glucose, plasma insulin, C-peptide, and HbAlc in mice. Moreover, treatment with PGPs increased the insulin sensitivity index in KKAy mice. Results indicated that PGPs possess significant hypoglycaemic effects and could be developed as a drug for preventing hyperlipidaemia and hyperglycaemia.
高血糖和高血脂是冠状动脉疾病和动脉粥样硬化的主要危险因素。桃胶多糖（PGPs）具有多种生物活性。在本研究中，用耐热α-淀粉酶提取PGPs，并对其降血脂和降血糖活性进行了研究。将PGPs或蒸馏水（对照组）每日一次灌胃给予KKAy小鼠，持续3周。口服PGPs可降低小鼠血清甘油三酯、胆固醇、低密度脂蛋白胆固醇、空腹血糖、血浆胰岛素、C肽和糖化血红蛋白的水平。此外，PGPs处理可提高KKAy小鼠的胰岛素敏感性指数。结果表明，PGPs具有显著的降血糖作用，可开发为预防高血脂和高血糖的药物。
