Department of Microbiology Laboratory, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China.
Department of Microbiology Laboratory, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China.
Int J Biol Macromol. 2014 Jul;68:48-9. doi: 10.1016/j.ijbiomac.2014.04.004. Epub 2014 Apr 13.
This study was performed to investigate the hypolipidemic effect of the polysaccharides extracted from Porphyra yezoensis. Male Sprague-Dawley rats were divided into three groups and orally treated with diets containing either high fat, P. yezoensis polysaccharides (PPs), or normal fat. Treatment of male Sprague-Dawley rats with PPs led not only to significant decreases in plasma triacylglycerol, total cholesterol, and plasma low-density lipoprotein cholesterol and an increase in plasma high-density lipoprotein cholesterol, but also to significant decreases in liver weight, triacylglycerol and cholesterol. Therefore, the results suggest that PPs had a high hypolipidemic activity and could be used as a potential therapeutic agent for hyperlipidemia.
本研究旨在探讨紫菜多糖的降血脂作用。雄性 Sprague-Dawley 大鼠分为三组，分别用含有高脂肪、紫菜多糖（PPs）或正常脂肪的饮食进行口服处理。用 PPs 处理雄性 Sprague-Dawley 大鼠不仅导致血浆三酰甘油、总胆固醇和血浆低密度脂蛋白胆固醇显著降低，血浆高密度脂蛋白胆固醇显著升高，而且还导致肝重、三酰甘油和胆固醇显著降低。因此，研究结果表明，PPs 具有很高的降血脂活性，可作为治疗高血脂的潜在药物。
