Wren Melissa A, Caskey John R, Liu David X, Embers Monica E
Division of Veterinary Medicine, Tulane National Primate Research Center, Tulane University, Covington, Louisiana, USA.
Comp Med. 2013;63(6):521-7.
A 5.5-y-old Chinese-origin female rhesus macaque (Macaca mulatta) presented for bilateral hindlimb lameness. The primate had been group-reared in an SPF breeding colony and was seronegative for Macacine herpesvirus 1, SIV, simian retrovirus type D, and simian T-lymphotropic virus. The macaque's previous medical history included multiple occasions of swelling in the left tarsus, and trauma to the right arm and bilateral hands. In addition, the macaque had experienced osteomyelitis of the left distal tibia and rupture of the right cranial cruciate ligament that had been surgically repaired. Abnormal physical examination findings on presentation included a thin body condition, mild dehydration, and bilaterally swollen stifles that were warm to the touch, with the right stifle more severely affected. Mild instability in the left stifle was noted, and decreased range of motion and muscle atrophy were present bilaterally. Hematologic findings included marked neutrophilia and lymphopenia and moderate anemia. Arthrocentesis and culture of joint fluid revealed Moraxella-like organisms. Treatment with enrofloxacin was initiated empirically and subsequently switched to cephalexin, which over time alleviated the joint swelling and inflammation. Definitive diagnosis of Moraxella osloensis septic arthritis was made through isolation of the organism and sequencing of the 16S rDNA region. To our knowledge, this report is the first description of Moraxella osloensis septic arthritis in a rhesus macaque.
一只5.5岁的中国原产雌性恒河猴（猕猴）因双侧后肢跛行前来就诊。这只灵长类动物在一个无特定病原体的繁殖群体中群居饲养，对猕猴疱疹病毒1、猴免疫缺陷病毒、D型猿猴逆转录病毒和猿猴嗜T淋巴细胞病毒血清学检测呈阴性。这只猕猴既往病史包括多次左跗骨肿胀，以及右臂和双手受伤。此外，这只猕猴曾患左胫骨远端骨髓炎和右颅交叉韧带断裂，并已接受手术修复。就诊时体格检查异常发现包括身体消瘦、轻度脱水，双侧膝关节肿胀，触之发热，右侧膝关节受累更严重。左侧膝关节有轻度不稳定，双侧均存在活动范围减小和肌肉萎缩。血液学检查结果包括明显的中性粒细胞增多和淋巴细胞减少以及中度贫血。关节穿刺和关节液培养发现类似莫拉菌属的微生物。经验性开始使用恩诺沙星治疗，随后改用头孢氨苄，随着时间推移，关节肿胀和炎症得到缓解。通过分离该微生物并对16S rDNA区域进行测序，明确诊断为奥斯陆莫拉菌败血症性关节炎。据我们所知，本报告是首例关于恒河猴奥斯陆莫拉菌败血症性关节炎的描述。
