Fu Q-Y, Ma L, Yang Z-B, Pao T
Treatment Center for Kidney Diseases, No. 281 Hospital of Chinese People's Liberation Army, 4 Xi hai tan Road, Beidaihe District, Qinhuangdao 066100, P. R, China.
Niger J Clin Pract. 2014 Jan-Feb;17(1):122-4. doi: 10.4103/1119-3077.122874.
We present a 27-year-old male with multiple organ dysfunction caused by parathyroid adenoma-induced primary hyperparathyroidism (PHPT). Initially, the patient experienced a sudden onset of gastrointestinal symptoms, polyuria, polydipsia, bone pain, renal dysfunction, nephrolithiasis, and acute pancreatitis, symptoms associated with hypercalcemia. Biochemical findings suggested PHPT. Renal biopsy showed an acute tubular injury and massive calcium deposits in the tubular epithelial cells and tubular lumina. Moreover, neck ultrasonography suggested the possibility of a parathyroid tumor. We excised his right parathyroid gland. Histopathological analysis revealed features of a parathyroid adenoma. Post-operatively this patient had normal serum calcium concentration, but was renally insufficient. A recent repeat biopsy showed chronic renal tubular injury. Our findings illustrate the complications of various systems that can occur in patients with PHPT caused by a parathyroid adenoma.
我们报告一名27岁男性，因甲状旁腺腺瘤引起的原发性甲状旁腺功能亢进症（PHPT）导致多器官功能障碍。最初，患者突然出现胃肠道症状、多尿、多饮、骨痛、肾功能不全、肾结石和急性胰腺炎，这些症状与高钙血症有关。生化检查结果提示PHPT。肾活检显示急性肾小管损伤，肾小管上皮细胞和管腔内有大量钙沉积。此外，颈部超声检查提示存在甲状旁腺肿瘤的可能性。我们切除了他的右甲状旁腺。组织病理学分析显示为甲状旁腺腺瘤特征。术后该患者血清钙浓度正常，但存在肾功能不全。最近再次活检显示为慢性肾小管损伤。我们的研究结果说明了由甲状旁腺腺瘤引起的PHPT患者可能出现的各种系统并发症。
