Division of Cardiovascular Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.
J Hypertens. 2014 Jan;32(1):82-9. doi: 10.1097/HJH.0b013e328365c8a8.
Night-time blood pressure (BP) is strongly associated with hypertensive target organ damage; however, no previous studies have compared home BP monitor measurements of the reduction in night-time BP induced by antihypertensive medications with those obtained with ambulatory BP monitors.
As part of the Japan Morning Surge-Target Organ Protection study, in which candesartan (thiazide diuretics were added, if needed) was administered to hypertensive patients in the morning or at bedtime, 50 hypertensive patients had their night-time home and ambulatory BP successfully measured at the baseline and 6 months. In addition, three night-time home BP readings were taken during sleeping hours (at 2, 3, and 4 o'clock) for 6 months.
The mean reduction in night-time BP did not differ significantly between home and ambulatory BP monitoring (10.4 ± 17.9/6.0 ± 12.0 vs. 13.3 ± 14.6/7.6 ± 8.9 mmHg, P = 0.219/0.344), but the differences varied among individual patients. The reduction in night-time BP according to home BP monitoring was significantly correlated with the value obtained with ambulatory BP monitoring (r = 0.51/0.38, P < 0.001/=0.006). The reduction in night-time SBP according to home BP monitoring was significantly correlated with the reductions in left ventricular mass index (r = 0.385, P = 0.013, N = 41) and Sokolow-Lyon voltage (r = 0.335, P = 0.035, N = 40).
Home BP monitoring produces estimates of mean night-time BP reductions comparable to those from ambulatory monitoring, while the differences varied among individual patients. The reduction in night-time home BP according to home BP monitoring is significantly correlated with the reduction in left ventricular hypertrophy.
夜间血压（BP）与高血压靶器官损害密切相关；然而，以前的研究尚未比较降压药物引起的夜间 BP 降低的家庭 BP 监测测量值与动态血压监测器获得的测量值。
作为坎地沙坦（如果需要，添加噻嗪类利尿剂）在早上或睡前给药的日本晨间高血压靶器官保护研究的一部分，50 名高血压患者在基线和 6 个月时成功测量了夜间家庭和动态血压。此外，在 6 个月内，有 3 次夜间家庭 BP 读数在睡眠期间（2、3 和 4 点）进行。
夜间 BP 降低在家庭和动态血压监测之间没有显著差异（10.4±17.9/6.0±12.0 与 13.3±14.6/7.6±8.9mmHg，P=0.219/0.344），但个体患者之间存在差异。根据家庭 BP 监测，夜间 BP 降低与使用动态 BP 监测获得的值显著相关（r=0.51/0.38，P<0.001/=0.006）。根据家庭 BP 监测，夜间 SBP 降低与左心室质量指数（r=0.385，P=0.013，N=41）和 Sokolow-Lyon 电压（r=0.335，P=0.035，N=40）的降低显著相关。
家庭 BP 监测可产生与动态监测相当的平均夜间 BP 降低估计值，而个体患者之间存在差异。根据家庭 BP 监测，夜间家庭 BP 降低与左心室肥厚降低显著相关。
