Chastonay P, Hurlimann J, Gardiol D
Virchows Arch A Pathol Anat Histopathol. 1986;410(3):221-9. doi: 10.1007/BF00710828.
Immunoperoxidase techniques were used to study, the distribution of peanut agglutinin receptors, blood group isoantigens and several epithelial antigens in hyperplasia, adenosis, microcarcinoma and well differentiated adenocarcinoma of the prostate. Intraluminal and luminal surface PNA receptors were seen in all well differentiated carcinomas, 53% of microcarcinomas and 50% of adenosis, while no such sites could be demonstrated in benign hyperplasia. The expected blood group isoantigen was expressed in 75% of benign hyperplasias. When compared to the hyperplastic epithelium nearby, appropriate ABH expression was seen in 60% of adenosis, 47% of microcarcinomas and 25% of well differentiated carcinomas. A keratin antibody specifically labelling the basal cells in the normal prostate identified a subset of well differentiated carcinomas with preferential staining of the apical cytoplasm while microcarcinomas and adenosis were consistently negative. Our study establishes a highly ordered PNA receptor distribution in prostatic epithelia; it confirms early changes in the expression of ABH isoantigens in epithelial proliferative disorders of the prostate; it identifies a subset of keratin-positive well differentiated carcinomas, possibly of different ontogeny.
免疫过氧化物酶技术被用于研究花生凝集素受体、血型同种抗原以及几种上皮抗原在前列腺增生、腺病、微癌和高分化腺癌中的分布。在所有高分化癌、53%的微癌和50%的腺病中可见管腔内和腔表面的PNA受体，而在良性增生中未发现此类部位。预期的血型同种抗原在75%的良性增生中表达。与附近的增生上皮相比，在60%的腺病、47%的微癌和25%的高分化癌中可见适当的ABH表达。一种特异性标记正常前列腺基底细胞的角蛋白抗体识别出一部分高分化癌，其顶端细胞质有优先染色，而微癌和腺病始终为阴性。我们的研究确定了前列腺上皮中高度有序的PNA受体分布；证实了前列腺上皮增殖性疾病中ABH同种抗原表达的早期变化；识别出一部分角蛋白阳性的高分化癌，可能具有不同的个体发生。
