Brawn P N
Cancer. 1982 Feb 15;49(4):826-33. doi: 10.1002/1097-0142(19820215)49:4<826::aid-cncr2820490436>3.0.co;2-i.
A ten-year period, 1966 through 1975, provided 2842 prostate specimens at The Wesley Medical Center, These specimens were classified as (1) adenocarcinoma, (2) adenosis, or (3) hyperplasia. During a follow-up period of 5--15 years (average 7.7 years), prostate carcinoma developed in seven of 108 patients (6.5%) with adenosis. During the same follow-up period prostate carcinoma developed in at least 84 of 2263 patients (3.7%) with hyperplasia. Adenosis is considered to be a dysplastic lesion because patients with histologic lesions limited to adenosis have approximately the same likelihood of prostate carcinoma developing as patients with hyperplasia.
1966年至1975年的十年间，卫斯理医疗中心提供了2842份前列腺标本。这些标本被分类为：(1)腺癌；(2)腺病；或(3)增生。在5至15年（平均7.7年）的随访期内，108例腺病患者中有7例（6.5%）发生了前列腺癌。在同一随访期内，2263例增生患者中至少有84例（3.7%）发生了前列腺癌。腺病被认为是一种发育异常病变，因为组织学病变仅限于腺病的患者发生前列腺癌的可能性与增生患者大致相同。
