Rummel Seth K, Ellsworth Rachel E
Clinical Breast Care Project, Windber Research Institute, 620 Seventh Street, Windber, PA 15963, USA; Clinical Breast Care Project, Windber Research Institute, 620 Seventh Street, Windber, PA 15963, USA.
Clinical Breast Care Project, Murtha Cancer Center, 620 Seventh Street, Windber, PA 15963, USA; Clinical Breast Care Project, Murtha Cancer Center, 620 Seventh Street, Windber, PA 15963, USA.
Future Sci OA. 2016 Mar 15;2(2):FSO107. doi: 10.4155/fsoa-2015-0012. eCollection 2016 Jun.
Since the first link between blood type and cancer was described in 1953, numerous studies have sought to determine whether the histoblood ABO group is associated with tumorigenesis. In 2009, the first significant association between a SNP located within the ABO glycosyltransferase gene and increased risk of pancreatic cancer was reported. Here, we describe the history and possible functions of the histoblood ABO group and then provide evidence for a role of blood group antigens in the most common cancer types worldwide using both blood type and SNP data. We also explore whether confusion regarding the role of blood type in cancer risk may be attributable to heterogeneity within tumor types.
自1953年首次描述血型与癌症之间的联系以来，众多研究一直试图确定组织血型ABO血型系统是否与肿瘤发生有关。2009年，有报道称ABO糖基转移酶基因内的一个单核苷酸多态性（SNP）与胰腺癌风险增加之间存在首个显著关联。在此，我们描述了组织血型ABO血型系统的历史和可能的功能，然后利用血型和SNP数据，为血型抗原在全球最常见癌症类型中的作用提供证据。我们还探讨了关于血型在癌症风险中作用的困惑是否可能归因于肿瘤类型内部的异质性。
