Taylor D E, Hargreaves J A, Ng L K, Sherbaniuk R W, Jewell L D
Am J Clin Pathol. 1987 Jan;87(1):49-54. doi: 10.1093/ajcp/87.1.49.
Gastric biopsy specimens were examined microbiologically and histologically for the presence of Campylobacter pyloridis. Of 51 randomly selected patients, 22 (43%) were found to harbor C. pyloridis in the gastric mucosa. The histologic demonstration of spiral organisms observed by staining with hematoxylin and eosin correlated well with microbiologic isolation of the organisms. There was a strong association (95.5%) between C. pyloridis in the gastric mucosa and histologically defined gastritis. However, there was no obvious association between C. pyloridis and ulcers. All C. pyloridis strains isolated exhibited uniform biochemical characteristics and had almost identical protein profiles, which indicated that they belong to a relatively homogeneous group distinct from other Campylobacter species. All C. pyloridis isolates were uniformly susceptible to ampicillin, amoxicillin, cephalothin, gentamicin, kanamycin, tetracycline, coumermycin, ciprofloxacin, novobiocin, clorobiocin, and nitrofurantoin. They were moderately resistant to nalidixic acid.
对胃活检标本进行了微生物学和组织学检查，以确定是否存在幽门弯曲菌。在随机选择的51例患者中，有22例（43%）被发现胃黏膜中存在幽门弯曲菌。通过苏木精和伊红染色观察到的螺旋状生物体的组织学表现与该生物体的微生物学分离结果密切相关。胃黏膜中的幽门弯曲菌与组织学定义的胃炎之间存在很强的关联（95.5%）。然而，幽门弯曲菌与溃疡之间没有明显关联。所有分离出的幽门弯曲菌菌株都表现出一致的生化特性，并且蛋白质谱几乎相同，这表明它们属于一个相对同质的群体，与其他弯曲菌属不同。所有幽门弯曲菌分离株对氨苄西林、阿莫西林、头孢噻吩、庆大霉素、卡那霉素、四环素、香豆霉素、环丙沙星、新生霉素、氯新生霉素和呋喃妥因均敏感。它们对萘啶酸有中度耐药性。
