Takashina T, Kanda Y, Hayakawa O, Kudo R, Ito E, Sagae S
Am J Obstet Gynecol. 1987 Jan;156(1):223-9. doi: 10.1016/0002-9378(87)90242-0.
In the present study a comparison was made between human yolk sacs and yolk sac tumors. Tubules surrounded by several to as many as 10 endodermal cells and intracellular tubules in one endodermal cell were frequently observed. The tubules were seen abundantly in the yolk sac of a 4-week pregnancy, and they resembled the reticular pattern of the yolk sac tumor. It was also observed that the papillary endoderm, which contained blood cells in the center and protruded into the endodermal tubules, resembled the Schiller-Duval body of yolk sac tumor. Ultrastructurally the tumor cells were similar to the yolk sac endoderm. alpha-Fetoprotein was positive in the yolk sac endoderm until approximately the seventh week of pregnancy. Yolk sac tumor was also alpha-fetoprotein-positive. In other words, our study of human yolk sacs of 4- to 11-week pregnancies presumes that the yolk sac tumor resembles the endoderm of 4- to 7-week pregnancies.
在本研究中，对人类卵黄囊和卵黄囊瘤进行了比较。经常观察到由几个到多达10个内胚层细胞包围的小管以及一个内胚层细胞内的细胞内小管。这些小管在妊娠4周的卵黄囊中大量可见，并且它们类似于卵黄囊瘤的网状结构。还观察到，中心含有血细胞并突入内胚层小管的乳头状内胚层类似于卵黄囊瘤的席勒-杜瓦尔体。在超微结构上，肿瘤细胞与卵黄囊内胚层相似。甲胎蛋白在妊娠约第7周之前在卵黄囊内胚层中呈阳性。卵黄囊瘤甲胎蛋白也呈阳性。换句话说，我们对妊娠4至11周的人类卵黄囊的研究推测，卵黄囊瘤类似于妊娠4至7周的内胚层。
