Albrechtsen R, Wewer U, Wimberley P D
Acta Pathol Microbiol Scand A. 1980 May;88(3):175-8. doi: 10.1111/j.1699-0463.1980.tb02483.x.
In this study of 4 human yolk sacs, the presence of hemoglobin A and F (HbA and HbF) is demonstrated for the first time in epithelial cells (type 1) and erythroid-like cells (type 2) in the endodermal layer by immunoperoxidase technique. Our findings strongly support the hypothesis previously proposed that the red blood cells formed in the yolk sac are of endodermal origin. Tumor with yolk sac differentiation (8 endodermal sinus tumors and 1 embryonal carcinoma with vitelline areas) similarly showed HbA and HbF localisation in endodermal cells. None of 59 germ cell tumors of other types contained these hemoglobins in the neoplastic cells.
在这项对4个人类卵黄囊的研究中，通过免疫过氧化物酶技术首次在内胚层的上皮细胞（1型）和类红细胞（2型）中证实了血红蛋白A和F（HbA和HbF）的存在。我们的研究结果有力地支持了先前提出的假说，即卵黄囊中形成的红细胞起源于内胚层。具有卵黄囊分化的肿瘤（8例内胚窦瘤和1例具有卵黄囊区域的胚胎癌）同样在内胚层细胞中显示出HbA和HbF的定位。其他类型的59例生殖细胞肿瘤中，肿瘤细胞均未含有这些血红蛋白。
