克服免疫抑制作为一种新的免疫治疗方法对抗胰腺癌。
Overcoming immunosuppression as a new immunotherapeutic approach against pancreatic cancer.
机构信息
Department of General Surgery; University of Heidelberg; Heidelberg, Germany.
出版信息
Oncoimmunology. 2013 Sep 1;2(9):e25736. doi: 10.4161/onci.25736. Epub 2013 Jul 23.
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of malignancy. Via a broad stimulation of the immune system, PDAC activates both antitumor immune responses and immunosuppressive mechanisms. We propose that new immunotherapeutic strategies for the management of PDAC should be designed to specifically neutralize the immunosuppressive tumor microenvironment.
摘要
胰腺导管腺癌 (PDAC) 是最致命的恶性肿瘤之一。通过广泛刺激免疫系统，PDAC 激活了抗肿瘤免疫反应和免疫抑制机制。我们提出，用于管理 PDAC 的新免疫治疗策略应该旨在专门中和免疫抑制性肿瘤微环境。
Zotero 插件