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抑制甲羟戊酸途径以克服化疗耐药性并促进癌细胞的免疫原性死亡：一石二鸟。

Inhibition of the mevalonate pathway to override chemoresistance and promote the immunogenic demise of cancer cells: Killing two birds with one stone.

机构信息

Department of Oncology; School of Medicine; University of Torino; Torino, Italy.

出版信息

Oncoimmunology. 2013 Sep 1;2(9):e25770. doi: 10.4161/onci.25770. Epub 2013 Jul 29.

DOI:10.4161/onci.25770
PMID:24327936
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3850498/
Abstract

The mevalonate pathway is an attractive target for cancer therapy not only to override multidrug resistance but also to promote the immunogenic demise of malignant cells. Recent data indicate that aminobisphosphonates are superior to statins for the pharmacological manipulation of the mevalonate pathway, since they exert therapeutically relevant effects on both cancer cells and the immune system.

摘要

甲羟戊酸途径不仅是克服多药耐药性的有吸引力的癌症治疗靶点，也是促进恶性细胞免疫原性死亡的靶点。最近的数据表明，氨基双膦酸盐在药理学上优于他汀类药物来调控甲羟戊酸途径，因为它们对癌细胞和免疫系统都有治疗相关的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b7/3850498/6b1d8898299c/onci-2-e25770-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b7/3850498/6b1d8898299c/onci-2-e25770-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b7/3850498/6b1d8898299c/onci-2-e25770-g1.jpg

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2
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J Immunol. 2011 Aug 15;187(4):1578-90. doi: 10.4049/jimmunol.1002514. Epub 2011 Jul 13.
3
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