Satoh J, Mizutani T, Morimatsu Y
Brain Dev. 1986;8(4):443-9. doi: 10.1016/s0387-7604(86)80067-5.
Twenty-two autopsy cases with developmental disabilities with history of infantile spasms were studied with special regard to brainstem lesions. Eleven out of 22 cases were considered to be of prenatal origin, ten cases were perinatal and one case had suffered from acute encephalopathy at six months of age. Some common pathological findings were noticed throughout the cases despite their various etiologies; small size of the brainstem tegmentum, spongy state in and around the central tegmental tract, localized periaqueductal glial scar. Control study on another autopsy series of 76 cases with developmental disabilities showed a close connection between these findings in the brainstem tegmentum and history of infantile spasms.
对22例有婴儿痉挛病史的发育障碍尸检病例进行了研究，特别关注脑干病变。22例中有11例被认为是产前起源，10例为围产期，1例在6个月大时患急性脑病。尽管病因各异，但在所有病例中都发现了一些常见的病理表现；脑干被盖体积小，中央被盖束及其周围呈海绵状，导水管周围局部胶质瘢痕形成。对另一组76例发育障碍尸检病例的对照研究表明，脑干被盖的这些表现与婴儿痉挛病史密切相关。
