Choi Won-Ku, Cho Dong-Hyu, Yim Chang-Yeol, Lee Na-Ri
Department of Obstetrics and Gynecology, Jeonbuk National University Hospital-Jeonbuk National University Medical School.
Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital.
Medicine (Baltimore). 2020 May;99(19):e20051. doi: 10.1097/MD.0000000000020051.
Hepatoid carcinoma of the ovary (HCO) is a rare disease that originates from the ovarian surface epithelium. It is histologically characterized as hepatocellular carcinoma (HCC) with a hepatocyte-rich granular cytoplasm.
A 65-year-old female patient was admitted with complaints of indigestion, abdominal bloating, and pain.
The patient showed an elevated level of serum alpha-fetoprotein (AFP) with abdominal bloating and pain. After surgery and histopathology analysis, she was finally diagnosed with HCO, Figo stage IC.
After cytoreductive surgery, she underwent adjuvant chemotherapy with carboplatin and paclitaxel. Although the disease was diagnosed at an early stage, it recurred 6 months after completion of adjuvant chemotherapy. Elevation of serum AFP level and removal of a mass from the lumbar vertebra confirmed the recurrence of this disease. Subsequently, the patient underwent radiation therapy and palliative chemotherapy.
She died 31 months after the diagnosis due to disease progression.
The aggressive nature of HCO was clearly observed in this case despite early diagnosis and treatment. Further studies are needed to understand the proper treatment and prognostic factors of HCO.
卵巢肝样癌（HCO）是一种起源于卵巢表面上皮的罕见疾病。其组织学特征为具有富含肝细胞的颗粒状细胞质的肝细胞癌（HCC）。
一名65岁女性患者因消化不良、腹胀和疼痛入院。
患者血清甲胎蛋白（AFP）水平升高，伴有腹胀和疼痛。经过手术及组织病理学分析，最终诊断为HCO，国际妇产科联盟（FIGO）分期为IC期。
减瘤手术后，她接受了卡铂和紫杉醇辅助化疗。尽管疾病在早期被诊断，但在辅助化疗完成6个月后复发。血清AFP水平升高及腰椎肿物切除证实了该疾病的复发。随后，患者接受了放射治疗和姑息化疗。
她在诊断后31个月因疾病进展死亡。
尽管早期诊断并治疗，但该病例中仍明显观察到HCO具有侵袭性。需要进一步研究以了解HCO的恰当治疗方法和预后因素。
