中国四川省 HPV 流行率和基因型分布及宫颈病理结果：HPV 疫苗大规模接种前三年的调查。
Prevalence and genotype distribution of HPV and cervical pathological results in Sichuan Province, China: a three years surveys prior to mass HPV vaccination.
机构信息
Departments of Cancer Research Laboratory, the Affiliated Hospital of Zunyi Medical University, No.149 Dalian Road, Zunyi, 563003, Guizhou Province, China.
Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, No. 32, West Second Section First Ring Rd., Chengdu, 610072, Sichuan, China.
出版信息
Virol J. 2020 Jul 10;17(1):100. doi: 10.1186/s12985-020-01366-2.
BACKGROUND
HPV persistent infection is a strong carcinogenic factor that can induce cervical cancer. Investigation of HPV epidemiology and genotype distribution is of great meaning for the development of cervical cancer prevention and control strategies.
METHODS
By using PCR-based hybridization gene chip assay, HPV genotype was detected from 14,185 women that came from HEC (Health Examination Center) or OGOC (Obstetrics and Gynecology Outpatient Clinics) between 2015 and 2017 in Sichuan area. The epidemiology and genotype distribution as well as the relationship between HPV infection and histology/cytology abnormalities were analyzed.
RESULTS
The positivity rate of HPV was 23.84%. The HPV-positive rate of OGOC group (37.62%) was significantly higher than that of HEC group (15.29%), p < 0.05. The prevalence of HPV reached peak at age 41-50 (5.86%) in HEC group, but at age 21-30 (14.74%) in OGOC group. Of all the HPV positive women, single genotype infection was the most common form in both HEC and OGOC group (62.06% in total screening population, 74.36% in HEC group and 54.01% in OGOC group). Three most prevalent HPV types were HPV-52 (5.02%), 58 (3.61%), and 16 (3.24%) in total screening population. Of all the HPV positive women, the top three types were HPV-52 (20.93%), CP8304 (15.32%), and 58 (14.42%) in HEC group, while were HPV-52 (21.14%), 16 (16.34%), and 58 (15.61%) in OGOC group. HPV 52/16/58 accounted for 41.84% of cytology and 56.52% of histological abnormalities.
CONCLUSIONS
Women in Sichuan area were facing the great threat of HPV infection, especially the women aged between 21 ~ 30 or 41-50 years old. The priority HPV types were HPV 52, 58, and 16 in OGOC group, while were HPV 52, CP8304, and 58 in HEC group. HPV 52/16/58 accounted for the majority of cytology and histological abnormalities. Our analysis was found to be valuable for providing a scientific basis for the prevention and control strategies of cervical cancer in Sichuan area.
背景
HPV 持续感染是一种强烈的致癌因素，可诱发宫颈癌。研究 HPV 的流行病学和基因型分布对于制定宫颈癌防治策略具有重要意义。
方法
采用基于 PCR 的杂交基因芯片检测法，对 2015 年至 2017 年期间来自四川地区 HEC（健康体检中心）或 OGOC（妇产科门诊）的 14185 名妇女的 HPV 基因型进行检测。分析 HPV 感染的流行病学和基因型分布以及与组织学/细胞学异常的关系。
结果
HPV 阳性率为 23.84%。OGOC 组 HPV 阳性率（37.62%）明显高于 HEC 组（15.29%），p<0.05。HEC 组 HPV 感染率在 41-50 岁达到高峰（5.86%），而 OGOC 组在 21-30 岁达到高峰（14.74%）。在所有 HPV 阳性妇女中，HEC 和 OGOC 组中以单一基因型感染最为常见（总筛查人群中为 62.06%，HEC 组为 74.36%，OGOC 组为 54.01%）。三种最常见的 HPV 类型是 HPV-52（5.02%）、58（3.61%）和 16（3.24%），占总筛查人群的 32.4%。在所有 HPV 阳性妇女中，HEC 组中最常见的三种类型是 HPV-52（20.93%）、CP8304（15.32%）和 58（14.42%），而 OGOC 组中最常见的三种类型是 HPV-52（21.14%）、16（16.34%）和 58（15.61%）。HPV 52/16/58 占细胞学异常的 41.84%，占组织学异常的 56.52%。
结论
四川地区妇女面临 HPV 感染的巨大威胁，尤其是 21-30 岁或 41-50 岁的妇女。OGOC 组的优先 HPV 型别为 HPV 52、58 和 16，而 HEC 组的优先 HPV 型别为 HPV 52、CP8304 和 58。HPV 52/16/58 占细胞学和组织学异常的大多数。我们的分析结果为四川地区宫颈癌防治策略的制定提供了科学依据。
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