Department of Medical Microbiology, Samsun University, Faculty of Medicine, Samsun, Turkey.
Department of Medical Genetics, Hitit University, Faculty of Medicine, Corum, Turkey.
Asian Pac J Cancer Prev. 2022 Jul 1;23(7):2477-2482. doi: 10.31557/APJCP.2022.23.7.2477.
The human papillomavirus (HPV) is an important public health problem that can cause cervical cancer. HPVs were classified into high-risk (HR-HPV) and low-risk (LR-HPV) types. In this study, we aimed to determine the prevalence and genotype distribution of HR-HPV infection in Samsun province in Turkey.
Cervical smear samples taken from 5406 women over a 23-month period were evaluated for the presence of HPV infection. The detection of HPV genotypes was performed using RT-PCR technology. HPV detection and genotyping were performed using RT-PCR method. HR- HPV types are divided into 3 groups as type 16, type 18 and other types (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, with or without type 16 and 18). The results were evaluated statistically.
The mean age of HR-HPV positive patients was 39.56 years (20-68 years). The prevalance of HR-HPV types did not differ between different age groups (p˃0.05). Overall, 9.17% of women (496/5406 samples) were found to be positive at least one type of HR-HPV. HPV type 16 was detected in 28.62%, type 18 in 9.67%, and other types in 78.83%. The most common HR-HPV type was other types (p˂0.001). Type 16 was most common than type 18 (p˂0.001). The patients were evaluated by dividing them into 6 age groups. Type 16 positivity was higher in 30-39 ages while type18 and other types positivity were higher in the 40-49 age group. When the 23-month period of HPV test was evaluated according to months and seasons, the highest prevalance was seen in June 2021 and Summer 2021.
To our knowledge, this is the first large-scale study of HR-HPV prevalence and genotype distribution among women in Samsun Province of Turkey. The other types containing one or more types made up the majority of the studied population.
人乳头瘤病毒（HPV）是一个重要的公共卫生问题，可以导致宫颈癌。HPV 被分为高危型（HR-HPV）和低危型（LR-HPV）。在这项研究中，我们旨在确定土耳其萨姆松省 HR-HPV 感染的流行率和基因型分布。
在 23 个月的时间里，对 5406 名女性的宫颈涂片样本进行了 HPV 感染的检测。使用 RT-PCR 技术检测 HPV 基因型。HPV 的检测和基因分型采用 RT-PCR 法进行。HR-HPV 类型分为 3 组：16 型、18 型和其他类型（31、33、35、39、45、51、52、56、58、59、66、68，伴有或不伴有 16 型和 18 型）。结果进行了统计学评估。
HR-HPV 阳性患者的平均年龄为 39.56 岁（20-68 岁）。不同年龄组的 HR-HPV 类型流行率无差异（p˃0.05）。总的来说，9.17%的女性（496/5406 样本）至少有一种 HR-HPV 类型呈阳性。HPV 16 型检出率为 28.62%，18 型检出率为 9.67%，其他型检出率为 78.83%。最常见的 HR-HPV 类型是其他类型（p˂0.001）。16 型比 18 型更常见（p˂0.001）。将患者分为 6 个年龄组进行评估。30-39 岁时 16 型阳性率较高，40-49 岁时 18 型和其他型阳性率较高。当按月份和季节评估 HPV 检测的 23 个月周期时，2021 年 6 月和夏季的阳性率最高。
据我们所知，这是土耳其萨姆松省首次对 HR-HPV 流行率和基因型分布进行的大规模研究。在研究人群中，含有一种或多种类型的其他类型占多数。
