Barlow Peter G, Findlay Emily Gwyer, Currie Silke M, Davidson Donald J
Health, Life & Social Sciences, Edinburgh Napier University, Sighthill Campus, Edinburgh, EH11 4BN, UK.
Future Microbiol. 2014;9(1):55-73. doi: 10.2217/fmb.13.135.
The global burden of morbidity and mortality arising from viral infections is high; however, the development of effective therapeutics has been slow. As our understanding of innate immunity has expanded over recent years, knowledge of natural host defenses against viral infections has started to offer potential for novel therapeutic strategies. An area of current research interest is in understanding the roles played by naturally occurring cationic host defense peptides, such as the cathelicidins, in these innate antiviral host defenses across different species. This research also has the potential to inform the design of novel synthetic antiviral peptide analogs and/or provide rationale for therapies aimed at boosting the natural production of these peptides. In this review, we will discuss our knowledge of the antiviral activities of cathelicidins, an important family of cationic host defense peptides, and consider the implications for novel antiviral therapeutic approaches.
病毒感染导致的全球发病和死亡负担很高；然而，有效治疗方法的开发进展缓慢。近年来，随着我们对固有免疫的理解不断扩展，关于宿主对病毒感染的天然防御机制的知识开始为新型治疗策略提供了潜力。当前研究的一个兴趣领域是了解天然存在的阳离子宿主防御肽，如cathelicidin，在不同物种的这些固有抗病毒宿主防御中所起的作用。这项研究还有可能为新型合成抗病毒肽类似物的设计提供信息和/或为旨在促进这些肽的天然产生的疗法提供理论依据。在这篇综述中，我们将讨论我们对cathelicidin（一种重要的阳离子宿主防御肽家族）抗病毒活性的了解，并考虑其对新型抗病毒治疗方法的影响。
