Bergman S, Medeiros L J, Radr T, Mangham D C, Lewandrowski K B
Department of Pathology, Massachusetts General Hospital, Boston 02114, USA.
Int J Pancreatol. 1995 Aug;18(1):71-5. doi: 10.1007/BF02825424.
We describe a malignant mucinous cystic neoplasm of the pancreas with ovarian-like stroma within which an osteoclast-like giant cell rich tumor arose. This rare tumor had a unique immunohistochemical profile with the giant cells staining for vimentin, leukocyte common antigen, and the monocyte/macrophage marker CD68, whereas the mucinous epithelium stained for epithelial membrane antigen and cytokeratin. The immunohistochemical findings are consistent with two lines of differentiation, one epithelial and the other suggesting mesenchymal differentiation of the giant cell tumor with an immunophenotype similar to giant cell tumor of bone. The coexistence of these two rare tumors suggests that they are histogenetically related. The findings of a giant cell tumor arising in the ovarian stroma indicates that the stroma of mucinous tumors is not always an innocuous component of the tumor.
我们描述了一例胰腺黏液性囊性肿瘤，伴有卵巢样间质，其中出现了富含破骨细胞样巨细胞的肿瘤。这种罕见肿瘤具有独特的免疫组化特征，巨细胞对波形蛋白、白细胞共同抗原和单核细胞/巨噬细胞标志物CD68呈阳性染色，而黏液上皮对上皮膜抗原和细胞角蛋白呈阳性染色。免疫组化结果符合两条分化途径，一条是上皮性的，另一条提示巨细胞瘤的间充质分化，其免疫表型类似于骨巨细胞瘤。这两种罕见肿瘤的共存提示它们在组织发生上相关。在卵巢间质中出现巨细胞瘤的结果表明，黏液性肿瘤的间质并非总是肿瘤的无害成分。
