光动力疗法治疗皮肤孢子丝菌病：一项体外和体内研究。
Cutaneous sporotrichosis treated with photodynamic therapy: an in vitro and in vivo study.
作者信息
Gilaberte Yolanda, Aspiroz Carmen, Alejandre M Carmen, Andres-Ciriano Elena, Fortuño Blanca, Charlez Luis, Revillo Maria Jose, Hamblin Michael R, Rezusta Antonio
机构信息
1 Unit of Dermatology, Hospital San Jorge , Huesca, Spain .
出版信息
Photomed Laser Surg. 2014 Jan;32(1):54-7. doi: 10.1089/pho.2013.3590. Epub 2013 Dec 13.
Abstract
BACKGROUND
Sporotrichosis is a fungal infection caused by Sporothrix schenckii complex, usually restricted to the skin, subcutaneous cellular tissue, and adjacent lymphatic vessels. Antimicrobial photodynamic therapy (aPDT) could be a good alternative to manage localized, superficial infections.
CASE REPORT
A 65-year-old African woman was diagnosed with a fixed cutaneous sporotrichosis on her left arm, treated with itraconazol and oral terbinafine with partial improvement. Topical 16% methyl aminolevulinate (MAL, Metvix(®))-PDT was used without success.
METHODS
An in vitro photoinactivation test with the isolated microorganism revealed phenothiazinium salts to be more effective than MAL.
CONCLUSIONS
PDT with intralesional 1% methylene blue (MB) in combination with intermittent low doses of itraconazole obtained complete microbiological and clinical response.
摘要
背景
孢子丝菌病是由申克孢子丝菌复合体引起的真菌感染，通常局限于皮肤、皮下细胞组织及相邻淋巴管。抗菌光动力疗法（aPDT）可能是治疗局限性浅表感染的一种良好替代方法。
病例报告
一名65岁的非洲女性被诊断为左臂固定性皮肤孢子丝菌病，接受伊曲康唑和口服特比萘芬治疗后有部分改善。外用16%甲基氨基酮戊酸（MAL，美克素（®））-光动力疗法治疗无效。
方法
对分离出的微生物进行体外光灭活试验，结果显示吩噻嗪盐比MAL更有效。
结论
病灶内注射1%亚甲蓝（MB）联合间歇性低剂量伊曲康唑的光动力疗法取得了完全的微生物学和临床疗效。
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