Romeo Umberto, Libotte Fabrizio, Palaia Gaspare, Galanakis Alexandros, Gaimari Gianfranco, Tenore Gianluca, Del Vecchio Alessandro, Polimeni Antonella
Department of Oral Sciences, "Sapienza" University of Rome , Rome, Italy .
Photomed Laser Surg. 2014 Jan;32(1):10-6. doi: 10.1089/pho.2013.3509. Epub 2013 Dec 14.
The purpose of this study was to compare secondary intention healing of oral soft tissues after laser surgery with and without the use of a compound containing amino acids and sodium hyaluronate.
Sodium hyaluronate has been successfully used in medicine to promote healing. It has not been studied in the healing of laser-produced wounds.
Excisional biopsy was performed in oral soft tissues with a potassium-titanyl-phosphate (KTP) laser (532 nm, SmartLite, DEKA, Florence, Italy) in 49 patients divided into two groups. In the study group (SG), 31 patients received a compound gel containing four amino acids and sodium hyaluronate (Aminogam(®), Errekappa, Italy) after laser surgery; in the control group (CG), 18 subjects received no treatment involving a drug or gel. Numeric rating scale (NRS) was used to evaluate pain experienced after surgery [pain index (PI)]. Using a grid as a benchmark and computer software, the lesion area was measured after surgery (T0) and after 7 days (T1). A percentage healing index (PHI) was calculated indicating healing extension in 7 days.
SG cases showed an average PHI of 64.38±26.50, whereas the average PHI in the CG was 47.88%±27.84. Mean PI was 2.67±0.96 for SG and 2.75±0.86 for CG. A statistically significant difference was detected between the groups for PHI (p=0.0447), whereas no difference was detectable for PI (p=0.77).
The use of a gel containing amino acids and sodium hyaluronate can promote faster healing via secondary intention in laser-induced wounds, although it does not seem to affect pain perception.
本研究旨在比较激光手术后使用和不使用含氨基酸及透明质酸钠化合物时口腔软组织的二期愈合情况。
透明质酸钠已成功用于医学领域促进愈合。但尚未在激光造成的伤口愈合方面进行研究。
对49例患者的口腔软组织进行磷酸钛钾（KTP）激光（532nm，SmartLite，DEKA，意大利佛罗伦萨）切除活检，将患者分为两组。研究组（SG）31例患者在激光手术后使用含四种氨基酸和透明质酸钠的复合凝胶（Aminogam®，Errekappa，意大利）；对照组（CG）18例受试者未接受任何药物或凝胶治疗。采用数字评分量表（NRS）评估术后疼痛感受[疼痛指数（PI）]。以网格为基准并使用计算机软件，在术后（T0）和7天后（T1）测量病变面积。计算愈合百分比指数（PHI）以表明7天内的愈合程度。
SG组的平均PHI为64.38±26.50，而CG组的平均PHI为47.88%±27.84。SG组的平均PI为2.67±0.96，CG组为2.75±0.86。两组间PHI有统计学显著差异（p = 0.0447），而PI无差异（p = 0.77）。
使用含氨基酸和透明质酸钠的凝胶可促进激光诱导伤口的二期愈合更快，但似乎不影响疼痛感知。
