酶促化学全合成及瑞鲍司因 C 的绝对构型重定。
Chemoenzymatic total synthesis and reassignment of the absolute configuration of ribisin C.
机构信息
Research School of Chemistry, Institute of Advanced Studies, The Australian National University , Canberra ACT 0200, Australia.
出版信息
Org Lett. 2014 Jan 3;16(1):228-31. doi: 10.1021/ol403220t. Epub 2013 Dec 16.
PMID:24329008
Abstract
The enantiomerically pure and enzymatically derived cis-1,2-dihydrocatechol 5 has been converted, by two related pathways, into compounds 3 and ent-3. As a result, it has been determined that the true structure of the natural product ribisin C is represented by ent-3.
摘要
手性纯的和酶衍生的顺式-1,2-二氢邻苯二酚 5 通过两种相关途径转化为化合物 3 和 ent-3。因此，已经确定天然产物里宾素 C 的真实结构由 ent-3 表示。
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