Klugmann F B, Decorti G, Candussio L, Grill V, Mallardi F, Baldini L
Br J Cancer. 1986 Nov;54(5):743-8. doi: 10.1038/bjc.1986.235.
The activity of theophylline and disodium cromoglycate was tested on adriamycin-induced histamine release in vitro and on adriamycin cardiotoxicity in vivo. Both substances significantly inhibited the release of histamine induced by 100 micrograms ml-1 of adriamycin on rat peritoneal cells and produced significant protection against adriamycin-mediated acute and chronic cardiotoxicity in mice. N-acetylcysteine, a free radical scavenger, successfully used in the prevention of the cardiomyopathy, was also found to be an inhibitor of histamine release induced by adriamycin and compound 48/80 on rat peritoneal cells. This study further supports the hypothesis that the release of histamine may be involved in the pathogenesis of anthracycline cardiotoxicity.
对茶碱和色甘酸钠进行了体外阿霉素诱导的组胺释放试验以及体内阿霉素心脏毒性试验。两种物质均能显著抑制100微克/毫升阿霉素诱导的大鼠腹腔细胞组胺释放，并对小鼠阿霉素介导的急性和慢性心脏毒性产生显著保护作用。N-乙酰半胱氨酸作为一种自由基清除剂，成功用于预防心肌病，也被发现是阿霉素和化合物48/80诱导的大鼠腹腔细胞组胺释放的抑制剂。本研究进一步支持了组胺释放可能参与蒽环类药物心脏毒性发病机制的假说。
