Sahakian B J, Sarna G S, Kantamaneni D B, Jackson A, Hutson P H, Curzon G
Brain Res. 1986 Dec 3;399(1):162-6. doi: 10.1016/0006-8993(86)90612-8.
Central 5-hydroxytryptamine (5-HT) and dopamine (DA) turnovers and tryptophan concentrations were estimated in individual male rats using repeated CSF withdrawal. On subsequent pairing, the major biters of each pair (neck + body bites) were predicted by their higher concentrations of the 5-HT precursor tryptophan but not by 5-HT turnover. However, bites/pair correlated highly significantly with the lower 5-HT and DA turnover values in each pair. The investigation illustrates a new and flexible approach to the neurochemistry of social behaviour.
利用重复采集脑脊液的方法，对雄性大鼠个体的中枢5-羟色胺（5-HT）和多巴胺（DA）周转率以及色氨酸浓度进行了评估。在随后的配对过程中，每对大鼠中主要撕咬者（颈部+身体撕咬）是由其较高浓度的5-HT前体色氨酸预测出来的，而非5-HT周转率。然而，每对大鼠的撕咬次数与每对中较低的5-HT和DA周转率数值高度显著相关。该研究阐明了一种研究社会行为神经化学的新的灵活方法。
