严重百日咳和白细胞增多：是否是时候进行交换了？
Severe pertussis and hyperleukocytosis: is it time to change for exchange?
机构信息
Pediatric Hematology Clinic and Coagulation Service, Western Galilee Hospital, Naharia, Israel; Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel.
出版信息
Transfusion. 2014 Jun;54(6):1630-3. doi: 10.1111/trf.12519. Epub 2013 Dec 16.
BACKGROUND
Pertussis is an important cause of infant death worldwide and continues to be a public health concern even in countries with high vaccination coverage. Severe (critical) pertussis with hyperleukocytosis is a severe form of the disease with up to 80% mortality rate. Attempts have been reported to reduce the white blood cell burden by exchange transfusion (ET) with conflicting conclusions.
CASE REPORT
We report a case of critical pertussis in a neonate who was treated with ET, in view of a comprehensive literature review.
RESULTS
The patient was discharged without any sequelae.
CONCLUSION
ET should be considered in all infants suffering from critical pertussis and hyperleukocytosis, even in secondary care community hospitals.
背景
百日咳是全球婴儿死亡的重要原因，即使在疫苗接种覆盖率高的国家，它仍然是一个公共卫生关注点。伴有白细胞增多的严重（危象性）百日咳是一种严重的疾病形式，死亡率高达 80%。据报道，通过换血（ET）可以尝试减轻白细胞负担，但结论存在争议。
病例报告
鉴于全面的文献综述，我们报告了一例危象性百日咳新生儿病例，该患者接受了 ET 治疗。
结果
患者出院时无任何后遗症。
结论
即使在二级社区医院，所有患有危象性百日咳和白细胞增多症的婴儿都应考虑进行 ET。
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