Pediatric Hematology Clinic and Coagulation Service, Western Galilee Hospital, Naharia, Israel; Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel.
Transfusion. 2014 Jun;54(6):1630-3. doi: 10.1111/trf.12519. Epub 2013 Dec 16.
Pertussis is an important cause of infant death worldwide and continues to be a public health concern even in countries with high vaccination coverage. Severe (critical) pertussis with hyperleukocytosis is a severe form of the disease with up to 80% mortality rate. Attempts have been reported to reduce the white blood cell burden by exchange transfusion (ET) with conflicting conclusions.
We report a case of critical pertussis in a neonate who was treated with ET, in view of a comprehensive literature review.
The patient was discharged without any sequelae.
ET should be considered in all infants suffering from critical pertussis and hyperleukocytosis, even in secondary care community hospitals.
百日咳是全球婴儿死亡的重要原因，即使在疫苗接种覆盖率高的国家，它仍然是一个公共卫生关注点。伴有白细胞增多的严重（危象性）百日咳是一种严重的疾病形式，死亡率高达 80%。据报道，通过换血（ET）可以尝试减轻白细胞负担，但结论存在争议。
鉴于全面的文献综述，我们报告了一例危象性百日咳新生儿病例，该患者接受了 ET 治疗。
患者出院时无任何后遗症。
即使在二级社区医院，所有患有危象性百日咳和白细胞增多症的婴儿都应考虑进行 ET。
