Han Hong-Wu, Wang Xi-Xia, Wang Ying, Zhang Wei-Hua
Department of Pediatric, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China.
Department of Pediatric Cardiovascular/Respiratory, Affiliated Rainbow Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China.
World J Clin Cases. 2025 Jun 16;13(17):102207. doi: 10.12998/wjcc.v13.i17.102207.
Pertussis is an acute respiratory infectious disease caused by . Although the diphtheria-pertussis-tetanus vaccine is widely administered, there are still a number of patients with severe pertussis each year, which can lead to death, especially in infants and young children. Hyperleukocytosis is a factor related to the severity of pertussis and a risk factor for death. Reducing the leukocyte number by plasma exchange is a treatment method in clinical practice.
Two children with pertussis with cough as the initial symptom, developed pneumonia during the course of the illness. White blood cell counts were significantly increased with the highest values of 87.34 × 10/L and 55.46 × 10/L. Following anti-infection, plasma exchange, and ventilator treatment, both children recovered.
Early identification of children with pertussis complicated with hyperleukocytosis and timely plasma exchange can improve the prognosis and reduce mortality.
百日咳是一种由……引起的急性呼吸道传染病。尽管白喉-百日咳-破伤风疫苗已广泛接种，但每年仍有许多重症百日咳患者，可导致死亡，尤其是婴幼儿。白细胞增多是与百日咳严重程度相关的因素及死亡危险因素。通过血浆置换降低白细胞数量是临床实践中的一种治疗方法。
两名以咳嗽为首发症状的百日咳患儿，病程中出现肺炎。白细胞计数显著升高，最高值分别为87.34×10⁹/L和55.46×10⁹/L。经过抗感染、血浆置换及呼吸机治疗后，两名患儿均康复。
早期识别合并白细胞增多的百日咳患儿并及时进行血浆置换可改善预后并降低死亡率。
