Dargenio R, Cimino C, Ragusa G, Garcea N, Stella C
Acta Eur Fertil. 1986 Jul-Aug;17(4):267-72.
In order to evaluate the preventive action of certain drugs in the formation of adhesions, three different types of trauma were induced in the uterine horns of 105 female Wistar rats. The animals were divided into six groups of 15 rats each and to each group was administered respectively: aprotinin i.p.; hydrocortisone i.p.; dextran 70 i.p.; colchicine i.p.; saline i.p.; colchicine i.m. One more group of 15 rats was left without treatment, as control. Four weeks later the adhesions were evaluated according to a qualitative/quantitative score and the results analysed using advanced statistical analysis. Aprotinin achieved the best results both in and around the trauma areas. Dextran produced an overall reduction of adhesions, but showed no specific effect on the trauma areas. The other substances failed to improve the adhesion situation.
为了评估某些药物在粘连形成中的预防作用，在105只雌性Wistar大鼠的子宫角诱导了三种不同类型的创伤。将动物分为六组，每组15只大鼠，分别给每组腹腔注射：抑肽酶；氢化可的松；右旋糖酐70；秋水仙碱；生理盐水；肌肉注射秋水仙碱。另外一组15只大鼠不进行治疗作为对照。四周后，根据定性/定量评分评估粘连情况，并使用先进的统计分析方法分析结果。抑肽酶在创伤区域及其周围均取得了最佳效果。右旋糖酐使粘连总体减少，但对创伤区域无特异性作用。其他物质未能改善粘连情况。
