De Leon F D, Toledo A A, Sanfilippo J S, Yussman M A
Fertil Steril. 1984 Apr;41(4):639-42. doi: 10.1016/s0015-0282(16)47792-7.
The efficacy of two nonsteroidal antiinflammatory drugs, ibuprofen and indomethacin, in the prevention of postoperative adhesions was examined. Thirty-three guinea pigs were randomly divided into three groups: a control group (n = 11), an ibuprofen group (n = 11), and an indomethacin group (n = 11). All of the animals received standardized injuries, and adhesions were graded 4 weeks later. Both treatment groups were found to have significantly fewer (P less than 0.01) adhesions when compared with the control group with no difference among the two treatment groups. It is concluded that ibuprofen and indomethacin are equally effective in reducing postoperative adhesions.
研究了两种非甾体抗炎药布洛芬和吲哚美辛预防术后粘连的疗效。33只豚鼠随机分为三组：对照组（n = 11）、布洛芬组（n = 11）和吲哚美辛组（n = 11）。所有动物均接受标准化损伤，4周后对粘连情况进行分级。与对照组相比，两个治疗组的粘连明显减少（P < 0.01），两个治疗组之间无差异。得出结论：布洛芬和吲哚美辛在减少术后粘连方面同样有效。
