Kevane Barry, Donnelly Jennifer, D'Alton Mary, Cooley Sharon, Preston Roger J S, Ní Ainle Fionnuala
J Perinat Med. 2014 Jul;42(4):417-25. doi: 10.1515/jpm-2013-0207.
To critically evaluate current understanding of risk factors for pregnancy-associated venous thromboembolism (VTE) and to describe underlying molecular mechanisms.
A literature search was undertaken using the national library of medicine PubMed database. The search terms used were "pregnancy" and "venous thromboembolism". Following exclusion of unsuitable data sources, studies were identified that described specific risk factors for pregnancy-associated VTE and suggested possible underlying molecular mechanisms. Adjusted odds ratios and incident rate ratios for these specific risk factors were identified in each study and tabulated.
A series of mainly retrospective cohort and case control studies over the past two decades have reported specific risk factors for pregnancy-associated VTE. Recent published literature has highlighted the interaction between commonly occurring risk factors, particularly the potential for a multiplicative effect on overall VTE risk, and have led to improvements in our understanding of the molecular mechanisms underlying these risk factors.
Mortality from pregnancy associated VTE continues despite prevention strategies. A detailed understanding of specific risk factors, their interactions and underlying molecular mechanisms is required to identify women at highest risk and to guide development of thromboprophylaxis strategies.
批判性地评估目前对妊娠相关静脉血栓栓塞症（VTE）危险因素的认识，并描述其潜在的分子机制。
使用美国国立医学图书馆的PubMed数据库进行文献检索。检索词为“妊娠”和“静脉血栓栓塞症”。在排除不合适的数据源后，确定了描述妊娠相关VTE特定危险因素并提出可能潜在分子机制的研究。在每项研究中确定这些特定危险因素的调整比值比和发病率比，并制成表格。
过去二十年的一系列主要为回顾性队列研究和病例对照研究报告了妊娠相关VTE的特定危险因素。最近发表的文献强调了常见危险因素之间的相互作用，特别是对总体VTE风险的潜在倍增效应，并增进了我们对这些危险因素潜在分子机制 的理解。
尽管采取了预防策略，妊娠相关VTE导致的死亡率仍持续存在。需要详细了解特定危险因素、它们之间的相互作用以及潜在的分子机制，以识别高危女性并指导血栓预防策略的制定。
