利用新型可见光激发荧光传感器在斑马鱼幼体中进行体内锌离子比率成像。
In vivo ratiometric Zn2+ imaging in zebrafish larvae using a new visible light excitable fluorescent sensor.
机构信息
State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China.
出版信息
Chem Commun (Camb). 2014 Feb 7;50(10):1253-5. doi: 10.1039/c3cc46262e.
PMID:24336489
Abstract
A visible light excitable ratiometric Zn(2+) sensor was developed by integrating a Zn(2+) chelator as the ICT donor of the fluorophore sulfamoylbenzoxadiazole, which displays the Zn(2+)-induced hypsochromic emission shift (40 nm) and favors the in vivo ratiometric Zn(2+) imaging in zebrafish larvae.
摘要
可见光谱激发的比率型 Zn(2+) 传感器通过将 Zn(2+) 螯合剂整合为荧光团磺酰胺苯并恶二唑的 ICT 供体来开发，该传感器显示出 Zn(2+) 诱导的蓝移发射（40nm），并有利于斑马鱼幼虫体内的比率型 Zn(2+) 成像。
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