Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Nat Prod Rep. 2014 Apr;31(4):419-32. doi: 10.1039/c3np70090a. Epub 2013 Dec 16.
The ability to procure useful quantities of a molecule by simple, scalable routes is emerging as an important goal in natural product synthesis. Approaches to molecules that yield substantial material enable collaborative investigations (such as SAR studies or eventual commercial production) and inherently spur innovation in chemistry. As such, when evaluating a natural product synthesis, scalability is becoming an increasingly important factor. In this Highlight, we discuss recent examples of natural product synthesis from our laboratory and others, where the preparation of gram-scale quantities of a target compound or a key intermediate allowed for a deeper understanding of biological activities or enabled further investigational collaborations.
通过简单、可扩展的路线获得大量有用分子的能力，正在成为天然产物合成中的一个重要目标。能够产生大量物质的分子方法能够促进合作研究（如 SAR 研究或最终的商业生产），并从本质上激发化学创新。因此，在评估天然产物合成时，可扩展性正成为一个越来越重要的因素。在这篇亮点文章中，我们讨论了来自我们实验室和其他实验室的天然产物合成的最新实例，其中目标化合物或关键中间体的克级制备允许对生物活性有更深入的了解，或能够进行进一步的合作研究。
