Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, PO Box 855, Perth, WA, 6872, Australia.
Cancer Causes Control. 2014 Mar;25(3):283-91. doi: 10.1007/s10552-013-0330-x. Epub 2013 Dec 12.
Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their etiology remains largely unknown. This study investigated whether household exposure to paints and floor treatments and parental occupational painting were associated with CBT risk in a population-based case-control study conducted between 2005 and 2010.
Cases were identified through all ten Australian pediatric oncology centers, and controls via nationwide random-digit dialing, frequency matched to cases on age, sex, and state of residence. Data were obtained from parents in mailed questionnaires and telephone interviews. Information on domestic painting and floor treatments, and parental occupational exposure to paint, in key periods relating to the index pregnancy and childhood was obtained for 306 cases and 950 controls. Data were analyzed using unconditional logistic regression, adjusting for frequency matching variables and potential confounders.
Overall, we found little evidence that parental, fetal, or childhood exposure to home painting or floor treatments was associated with risk of CBT. There was, though, some evidence of a positive association between childhood exposure to indoor painting and risk of high-grade glioma [odds ratio (OR) 3.31, 95 % confidence interval (CI) 1.29, 8.52] based on very small numbers. The OR for the association between CBT and paternal occupational exposure to paint any time before the pregnancy was 1.32 (95 % CI 0.90, 1.92), which is consistent with the results of other studies.
Overall, we found little evidence of associations between household exposure to paint and the risk of CBT in any of the time periods investigated.
儿童脑肿瘤（CBT）是儿童癌症死亡的主要原因，但病因仍很大程度上未知。本研究通过 2005 年至 2010 年期间进行的一项基于人群的病例对照研究，调查了家庭暴露于油漆和地板处理剂以及父母职业性油漆刷涂是否与 CBT 风险相关。
病例通过澳大利亚十个儿科肿瘤中心确定，对照组通过全国随机数字拨号确定，按年龄、性别和居住州与病例频数匹配。通过邮寄问卷和电话访谈从父母那里获取有关家庭油漆和地板处理以及父母职业性油漆暴露的信息，这些信息与关键时期有关，包括索引妊娠和儿童期。共对 306 例病例和 950 例对照进行了分析。使用非条件逻辑回归分析数据，调整频数匹配变量和潜在混杂因素。
总体而言，我们发现父母、胎儿或儿童期暴露于家庭油漆或地板处理剂与 CBT 风险之间几乎没有关联的证据。不过，基于数量很少的证据，有一些儿童期暴露于室内油漆与高级别神经胶质瘤风险之间存在正相关的迹象[比值比（OR）3.31，95%置信区间（CI）1.29，8.52]。CBT 与父亲在怀孕前任何时间职业性油漆接触的关联的 OR 为 1.32（95%CI 0.90，1.92），这与其他研究的结果一致。
总体而言，我们在调查的任何时间段都发现家庭暴露于油漆与 CBT 风险之间几乎没有关联的证据。
