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A monoclonal antibody (1B7) specific for polymorphic determinant on mouse I-A antigens recognizes monomorphic epitope shared by most of RT-1 haplotypes in rats.

作者信息

Iwabuchi K, Ishikawa N, Mizuno K, Kojima H, Natori T, Ogasawara K, Ogasawara M, Fujita M, Onoé K

出版信息

Tissue Antigens. 1986 Oct;28(4):233-6. doi: 10.1111/j.1399-0039.1986.tb00488.x.

DOI:10.1111/j.1399-0039.1986.tb00488.x
PMID:2433809
Abstract

A monoclonal antibody, 1B7, which was established by immunizing C57BL/10 mice with splenocytes from B10.BR, was investigated by serological, immunochemical and functional analyses in mouse, rat, guinea pig and human systems. 1B7 recognized a polymorphic determinant on class II antigens in the mouse system. In the rat system, however, this antibody appeared to recognize a monomorphic epitope shared by all RT-1 haplotypes. 1B7 showed no reactivity in the human and guinea pig strains tested.

摘要

相似文献

1
A monoclonal antibody (1B7) specific for polymorphic determinant on mouse I-A antigens recognizes monomorphic epitope shared by most of RT-1 haplotypes in rats.
Tissue Antigens. 1986 Oct;28(4):233-6. doi: 10.1111/j.1399-0039.1986.tb00488.x.
2
Monoclonal antibodies detect polymorphic determinants shared by I-A and I-E antigens.单克隆抗体可检测I-A和I-E抗原共有的多态性决定簇。
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