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一种针对HLA - DR产物的单克隆抗体识别小鼠中的一种多态性Ia决定簇。

A monoclonal antibody to the HLA-DR product recognizes a polymorphic Ia determinant in mice.

作者信息

Brickell P M, McConnell I, Milstein C, Wright B

出版信息

Immunology. 1981 Jul;43(3):493-501.

PMID:6166548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1555060/
Abstract

A rat monoclonal antibody which recognizes a product of the HLA-DR locus is described. The determinant recognized by this antibody is monomorphic in man but polymorphic in mice. Mapping studies with inbred and recombinant strains of mice show that this antigen as associated with H-2 haplotypes b, d and q and is coded for by genes within the I-A subregion.

摘要

描述了一种识别HLA - DR位点产物的大鼠单克隆抗体。该抗体识别的决定簇在人类中是单态的，但在小鼠中是多态的。对近交系和重组系小鼠的定位研究表明，这种抗原与H - 2单倍型b、d和q相关，并由I - A亚区内的基因编码。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae7/1555060/50103a9646df/immunology00240-0090-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae7/1555060/d54fa87a526d/immunology00240-0089-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae7/1555060/50103a9646df/immunology00240-0090-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae7/1555060/d54fa87a526d/immunology00240-0089-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dae7/1555060/50103a9646df/immunology00240-0090-a.jpg

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本文引用的文献

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Epidermal T lymphocytes and dendritic cells in chronic plaque psoriasis: the effects of PUVA treatment.慢性斑块状银屑病中的表皮T淋巴细胞和树突状细胞：补骨脂素紫外线A光化学疗法（PUVA）治疗的效果
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