Department of Neurology, State University of New York-Downstate Medical Center, Box 1213 450 Clarkson Ave., Brooklyn, NY, 11203, USA,
J Neurovirol. 2013 Dec;19(6):574-85. doi: 10.1007/s13365-013-0219-1. Epub 2013 Dec 12.
This study aimed to explore the relationship of body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) with cognition in women with (HIV+) and without HIV (HIV-) infection. One thousand six hundred ninety participants (1,196 HIV+, 494 HIV-) in the Women's Interagency HIV Study (WIHS) with data available on anthropometric measures comprise the analytical sample. Cross-sectional analyses using linear regression models estimated the relationship between anthropometric variables and Trails A, Trails B, Stroop interference time, Stroop word recall, Stroop color naming and reading, and Symbol Digit Modalities Test (SDMT) with consideration for age, HIV infection status, Wide Range Achievement Test score, CD4 count, insulin resistance, drug use, and race/ethnicity. Among HIV+ women, BMI < 18.5 kg/m(2) was associated with poorer cognitive performance evidenced by longer Trails A and Trails B and shorter SDMT completion times. An obese BMI (30 kg/m(2) or higher) was related to better performance on Trails B and worse performance on the Stroop interference test. Among HIV- women, an obese BMI was related to worse performance on the Stroop color naming test. Few and inconsistent associations were observed between WC, WHR, and cognition. Among women at mid-life with chronic (at least 10 years) HIV infection, common anthropometric measures, primarily BMI, were differentially related to cognitive test performance by cognitive domain. Higher levels of BMI were associated with better cognitive function. In this era of antiretroviral therapies, restoration of health evidenced as higher BMI due to effective antiretroviral therapies, may improve cognitive function in middle-aged HIV-infected women.
本研究旨在探讨身体质量指数（BMI）、腰围（WC）和腰臀比（WHR）与 HIV 感染和未感染妇女认知功能的关系。妇女健康倡议研究（WIHS）中的 1690 名参与者（1196 名 HIV+，494 名 HIV-）具有可用的人体测量学数据，构成了分析样本。使用线性回归模型进行的横断面分析估计了人体测量变量与 Trails A、Trails B、Stroop 干扰时间、Stroop 单词回忆、Stroop 颜色命名和阅读以及符号数字模态测试（SDMT）之间的关系，同时考虑了年龄、HIV 感染状况、宽范围成就测试得分、CD4 计数、胰岛素抵抗、药物使用和种族/民族。在 HIV+女性中，BMI<18.5 kg/m2与认知表现较差有关，表现为 Trails A 和 Trails B 时间延长，SDMT 完成时间缩短。肥胖 BMI（30 kg/m2或更高）与 Trails B 表现较好和 Stroop 干扰测试表现较差有关。在 HIV-女性中，肥胖 BMI 与 Stroop 颜色命名测试表现较差有关。WC 和 WHR 与认知之间的关联很少且不一致。在患有慢性（至少 10 年）HIV 感染的中年女性中，常见的人体测量学指标，主要是 BMI，根据认知域的不同与认知测试表现相关。较高的 BMI 与更好的认知功能相关。在抗逆转录病毒治疗的时代，由于有效的抗逆转录病毒治疗导致健康状况恢复，即 BMI 升高，可能会改善中年 HIV 感染女性的认知功能。
