Vaughan Roger A, Mermier Christine M, Bisoffi Marco, Trujillo Kristina A, Conn Carole A
Department of Health, Exercise and Sports Science, University of New Mexico, 1 University Blvd, Albuquerque, NM, 87131, USA,
J Physiol Biochem. 2014 Mar;70(1):271-84. doi: 10.1007/s13105-013-0301-4. Epub 2013 Dec 13.
Mitochondrial dysfunction has been linked to many diseases including metabolic diseases such as diabetes. Peroxisome proliferator-activated receptor gamma co-activator 1 (PGC-1) is a superfamily of transcriptional co-activators which are important precursors to mitochondrial biosynthesis found in most cells including skeletal muscle. The PGC-1 superfamily consists of three variants all of which are directly involved in controlling metabolic gene expression including those regulating fatty acid oxidation and mitochondrial proteins. In contrast to previous reviews on PGC-1, this mini-review summarizes the current knowledge of many known dietary stimulators of PGC-1 and the subsequent mitochondrial biosynthesis with associated metabolic benefit in skeletal muscle.
线粒体功能障碍与包括糖尿病等代谢性疾病在内的多种疾病有关。过氧化物酶体增殖物激活受体γ共激活因子1（PGC-1）是一类转录共激活因子超家族，是包括骨骼肌在内的大多数细胞中线粒体生物合成的重要前体。PGC-1超家族由三个变体组成，所有这些变体都直接参与控制代谢基因的表达，包括那些调节脂肪酸氧化和线粒体蛋白的基因。与之前关于PGC-1的综述不同，本综述总结了目前已知的许多PGC-1饮食刺激物以及随后骨骼肌中线粒体生物合成及其相关代谢益处的现有知识。
