Gong Y, Cao Y, Song L, Zhou J, Wang C, Wu B
Gastrointestinal Department of Southern Building, PLA General Hospital, Beijing, China.
Genet Mol Res. 2013 Dec 2;12(4):6032-9. doi: 10.4238/2013.December.2.1.
Gastric cancer is a major health problem worldwide; it is the second most common cause of cancer death in the world. Recent studies indicate that the high-mobility group (HMG) of chromosomal proteins is associated with cancer progression. However, HMGB3 has been little studied. We analyzed the co-expression network between HMGB3 and differentially-expressed genes in the GSE17187 database, identifying the relevant transcription factors, and the conserved domain of HMGB3 to understand the underlying regulation mechanisms involved in gastric cancer. Thirty-one relationships between 11 differentially-expressed genes were included in a co-expression network; many of these genes have been identified as related to cancer, including TBX5 and TFR2. Further analysis identified nine transcription factors, these being GATA3, MZF1, GATA1, GATA2, SRY, REL, NFYB, NFYC, and NFYA, which could interact with HMGB3 to regulate target gene expression and consequently regulate gastric cancer cell proliferation, migration and invasion. The HMG-box domain was very similar in various species, with only a few amino acid changes, indicating conserved functions in HMG-box. This information helps to provide insight into the molecular mechanisms of HMGB3 in human gastric cancer.
胃癌是全球主要的健康问题；它是全球癌症死亡的第二大常见原因。最近的研究表明，染色体蛋白的高迁移率族（HMG）与癌症进展有关。然而，HMGB3的研究较少。我们在GSE17187数据库中分析了HMGB3与差异表达基因之间的共表达网络，确定了相关转录因子以及HMGB3的保守结构域，以了解胃癌潜在的调控机制。11个差异表达基因之间的31种关系被纳入共表达网络；其中许多基因已被确定与癌症相关，包括TBX5和TFR2。进一步分析确定了9种转录因子，即GATA3、MZF1、GATA1、GATA2、SRY、REL、NFYB、NFYC和NFYA，它们可与HMGB3相互作用以调节靶基因表达，从而调控胃癌细胞的增殖、迁移和侵袭。HMG盒结构域在不同物种中非常相似，只有少数氨基酸变化，表明HMG盒具有保守功能。这些信息有助于深入了解HMGB3在人类胃癌中的分子机制。
