Texas Tech University Health Sciences Center - Paul L. Foster School of Medicine, El Paso, TX, 79905, USA,
Curr Allergy Asthma Rep. 2014 Jan;14(1):409. doi: 10.1007/s11882-013-0409-1.
Noninfectious uveitis encompasses a diverse group of ocular inflammatory disorders that share an underlying immune etiology and may be associated with systemic disease or confined primarily to the eye. Uveitis is commonly classified by anatomical location of inflammation into anterior, intermediate, posterior, and panuveitis. The treatment of noninfectious uveitis consists of corticosteroids, immunosuppressive agents, and surgically placed steroid implants. We review the epidemiology, immunopathology, and clinical features of several noninfectious immune-mediated uveitides, including HLA-B27 acute anterior uveitis, juvenile idiopathic arthritis, intermediate uveitis, sarcoidosis, Behcet's disease, Vogt-Koyanagi-Harada syndrome, sympathetic ophthalmia, and white dot syndromes. We also discuss the stepwise approach to medical treatment of immune-mediated uveitis as well as the characteristics, safety, and efficacy of immunosuppressive agents used to treat ocular inflammatory disease.
非感染性葡萄膜炎包括一大类眼部炎症性疾病，它们具有共同的潜在免疫病因，可能与系统性疾病有关或主要局限于眼部。葡萄膜炎通常根据炎症的解剖位置分为前葡萄膜炎、中间葡萄膜炎、后葡萄膜炎和全葡萄膜炎。非感染性葡萄膜炎的治疗包括皮质类固醇、免疫抑制剂和手术植入皮质类固醇。我们回顾了几种非感染性免疫介导性葡萄膜炎的流行病学、免疫病理学和临床特征，包括 HLA-B27 急性前葡萄膜炎、幼年特发性关节炎、中间葡萄膜炎、结节病、贝切特病、Vogt-Koyanagi-Harada 综合征、交感性眼炎和白点综合征。我们还讨论了免疫介导性葡萄膜炎的阶梯式治疗方法，以及用于治疗眼部炎症性疾病的免疫抑制剂的特点、安全性和疗效。
