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儿童电压门控钾通道抗体阳性自身免疫性脑病:一例病例报告及对一种未被充分认识疾病的文献综述

Voltage gated potassium channel antibodies positive autoimmune encephalopathy in a child: A case report and literature review of an under-recognized condition.

作者信息

Ganesan Subramanian, Beri Sushil, Khan Beri, Hussain Nahin

机构信息

Department of Paediatric Neurology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.

出版信息

Ann Indian Acad Neurol. 2013 Oct;16(4):593-6. doi: 10.4103/0972-2327.120483.

Abstract

Autoimmune limbic encephalitis (LE) associated with voltage gated potassium channel antibodies (VGKC-Abs) in children is more common than previously thought and is not always paraneoplastic. Non-neoplastic, autoimmune LE associated with VGKC-Abs has been described recently. However, only few case reports in children as the disease is predominantly described in the adult population. It is likely that this type of autoimmune encephalitis is currently under-diagnosed and hence, under-treated, especially in children. We present a 13-year-old previously fit and healthy African girl diagnosed with LE and we reviewed the literature for its current management.

摘要

儿童中与电压门控钾通道抗体(VGKC-Abs)相关的自身免疫性边缘叶脑炎(LE)比之前认为的更为常见,且并不总是副肿瘤性的。近期已有关于与VGKC-Abs相关的非肿瘤性自身免疫性LE的描述。然而,由于该疾病主要在成人中被描述,儿童中的病例报告很少。这种类型的自身免疫性脑炎目前很可能诊断不足,因此治疗也不足,尤其是在儿童中。我们报告一名13岁既往健康的非洲女孩被诊断为LE,并回顾了其当前治疗的文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e07c/3841607/bcca528d499f/AIAN-16-593-g001.jpg

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