Chou Yuan-Hwa, Yang Bang-Hung, Chung Ming-Yi, Chen Shih-Pei, Su Tung-Ping, Chen Chia-Chieh, Wang Shyh-Jen
Department of Psychiatry, Taipei Veterans General Hospital & National Yang Ming University, Taipei, Taiwan.
Psychiatry Res. 2009 Apr 30;172(1):38-43. doi: 10.1016/j.pscychresns.2008.12.006. Epub 2009 Feb 23.
The aim of this study was to examine the feasibility of (123)I-ADAM to image the serotonin transporter (SERT) in Asian (Taiwanese) subjects. Single photon emission computed tomography (SPECT) scans were performed on nine healthy volunteers who were s-allele carriers at the polymorphism within the serotonin transporter promoter region (SERTPR) after intravenous bolus injection of (123)I-ADAM. Quantification of (123)I-ADAM binding was performed using the ratio equilibrium method (REM) with specific uptake ratio (SUR) and a simplified reference tissue model (SRTM). Curve-fitting techniques were used to obtain the peak equilibrium point from 241 to 301 min (average 264+/-20 min) after injection of (123)I-ADAM for the midbrain and from 215 to 270 min (average 235+/-18 min) after injection of (123)I-ADAM for the striatum. Two sets of SUR were obtained by either curve fitting (estimated values) or integrated period from 240 to 270 min (observed values). The estimated values of SUR were 2.11+/-0.51 for the midbrain and 1.50+/-0.44 for the striatum, whereas the observed values were 2.11+/-0.83 for the midbrain and 1.24+/-0.31 for the striatum. The SRTM showed that the binding potential (BP) was 2.10+/-0.66 for the midbrain and 1.35+/-0.25 for the striatum. There was a good correlation between estimated SUR, observed SUR and SRTM in the midbrain but not in the striatum. The optimal scanning duration for both the midbrain and the striatum should be 220 to 280 min similar to that suggested by previous studies in Caucasians. However, due to the low signal-to-noise ratio in the striatum, (123)I-ADAM could be an ideal tracer for imaging SERT in the midbrain but not in the striatum.
本研究的目的是探讨（123）I-ADAM对亚洲（台湾）受试者血清素转运体（SERT）进行成像的可行性。对9名健康志愿者进行单光子发射计算机断层扫描（SPECT），这些志愿者是血清素转运体启动子区域（SERTPR）多态性的s等位基因携带者，在静脉推注（123）I-ADAM后进行扫描。使用比率平衡法（REM）、特异性摄取率（SUR）和简化参考组织模型（SRTM）对（123）I-ADAM结合进行定量。采用曲线拟合技术在注射（123）I-ADAM后241至301分钟（平均264±20分钟）获取中脑的峰值平衡点，在注射（123）I-ADAM后215至270分钟（平均235±18分钟）获取纹状体的峰值平衡点。通过曲线拟合（估计值）或240至270分钟的积分时间段（观测值）获得两组SUR。中脑SUR的估计值为2.11±0.51，纹状体为1.50±0.44，而中脑的观测值为2.11±0.83，纹状体为1.24±0.31。SRTM显示，中脑的结合潜能（BP）为2.10±0.66，纹状体为1.35±0.25。中脑的估计SUR、观测SUR和SRTM之间存在良好的相关性，但纹状体中不存在。中脑和纹状体的最佳扫描持续时间应为220至280分钟，这与先前针对高加索人的研究所建议的相似。然而，由于纹状体中的信噪比低，（123）I-ADAM可能是中脑而非纹状体中SERT成像的理想示踪剂。
