711th Human Performance Wing, Optical Radiation Branch, 4141 Petroleum Road, JBSA Fort Sam Houston, Texas 78234.
TASC Inc., 4241 Woodcock Drive, Suite B-100, San Antonio, Texas 78228.
J Biomed Opt. 2013 Dec;18(12):125002. doi: 10.1117/1.JBO.18.12.125002.
A series of experiments were conducted in vivo using Yucatan miniature pigs (Sus scrofa domestica) to determine thermal damage thresholds to the skin from 1319-nm continuous-wave Nd:YAG laser irradiation. Experiments employed exposure durations of 0.25, 1.0, 2.5, and 10 s and beam diameters of ∼0.6 and 1 cm. Thermal imagery data provided a time-dependent surface temperature response from the laser. A damage endpoint of fifty percent probability of a minimally visible effect was used to determine threshold for damage at 1 and 24 h postexposure. Predicted thermal response and damage thresholds are compared with a numerical model of optical-thermal interaction. Resultant trends with respect to exposure duration and beam diameter are compared with current standardized exposure limits for laser safety. Mathematical modeling agreed well with experimental data, predicting that though laser safety standards are sufficient for exposures <10 s, they may become less safe for very long exposures.
采用活体犹他微型猪(Sus scrofa domestica)进行了一系列实验,以确定 1319nm 连续波 Nd:YAG 激光照射皮肤的热损伤阈值。实验采用 0.25、1.0、2.5 和 10s 的照射持续时间和 ∼0.6 和 1cm 的光束直径。热成像数据提供了激光的时变表面温度响应。使用最小可见效应的 50%概率的损伤终点来确定 1 和 24 小时后暴露的损伤阈值。预测的热响应和损伤阈值与光热相互作用的数值模型进行了比较。关于暴露持续时间和光束直径的结果趋势与当前激光安全的标准暴露限制进行了比较。数学模型与实验数据吻合良好,预测尽管激光安全标准对于<10s 的暴露是足够的,但对于非常长的暴露,它们可能变得不太安全。