Department of Physics, University of Hong Kong, Pokfulam Road, Hong Kong.
Small. 2014 Mar 26;10(6):1171-83. doi: 10.1002/smll.201302434. Epub 2013 Dec 17.
The toxicity of metal oxide nanomaterials and their antimicrobial activity is attracting increasing attention. Among these materials, MgO is particularly interesting as a low cost, environmentally-friendly material. The toxicity of MgO, similar to other metal oxide nanomaterials, is commonly attributed to the production of reactive oxygen species (ROS). We investigated the toxicity of three different MgO nanoparticle samples, and clearly demonstrated robust toxicity towards Escherichia coli bacterial cells in the absence of ROS production for two MgO nanoparticle samples. Proteomics data also clearly demonstrate the absence of oxidative stress and indicate that the primary mechanism of cell death is related to the cell membrane damage, which does not appear to be due to lipid peroxidation.
金属氧化物纳米材料的毒性及其抗菌活性正引起越来越多的关注。在这些材料中，氧化镁作为一种低成本、环保的材料尤为引人注目。氧化镁与其他金属氧化物纳米材料一样，其毒性通常归因于活性氧物质 (ROS) 的产生。我们研究了三种不同氧化镁纳米颗粒样品的毒性，结果清楚地表明，在没有 ROS 产生的情况下，两种氧化镁纳米颗粒样品对大肠杆菌细菌细胞具有很强的毒性。蛋白质组学数据也清楚地表明不存在氧化应激，并表明细胞死亡的主要机制与细胞膜损伤有关，这似乎不是由于脂质过氧化引起的。
