Khalid Asma, Tomljenovic-Hanic Snjezana
School of Physics, University of Melbourne, Parkville, VIC 3010, Australia.
School of Science, RMIT University, Melbourne, VIC 3001, Australia.
Molecules. 2024 Nov 26;29(23):5594. doi: 10.3390/molecules29235594.
Fluorescence-based techniques have great potential in the field of bioimaging and could bring tremendous progress in microbiology and biomedicine. The most essential element in these techniques is fluorescent nanomaterials. The use of fluorescent nanoparticles as contrast agents for bioimaging is a large topic to cover. The purpose of this mini-review is to give the reader an overview of biocompatible and biodegradable fluorescent nanoparticles that are emerging nanomaterials for use in fluorescent bioimaging. In addition to the biocompatibility of these nanomaterials, biodegradability is considered a necessity for short-term sustainable bioimaging. Firstly, the main requirements for bioimaging are raised, and a few existing fluorescent nanoprobes are discussed. Secondly, a few inert biocompatible fluorescent nanomaterials for long-term bioimaging that have been, to some extent, demonstrated as fluorescent probes are reviewed. Finally, a few biocompatible and biodegradable nanomaterials for short-term bioimaging that are evolving for bioimaging applications are discussed. Together, these advancements signal a transformative leap toward sustainability and functionality in biomedical imaging.
基于荧光的技术在生物成像领域具有巨大潜力，能够在微生物学和生物医学方面带来巨大进展。这些技术中最关键的要素是荧光纳米材料。将荧光纳米颗粒用作生物成像的造影剂是一个涵盖面很广的主题。本小型综述的目的是让读者了解生物相容性和可生物降解的荧光纳米颗粒，它们是用于荧光生物成像的新兴纳米材料。除了这些纳米材料的生物相容性外，可生物降解性被认为是短期可持续生物成像的必要条件。首先，提出了生物成像的主要要求，并讨论了一些现有的荧光纳米探针。其次，综述了一些在一定程度上已被证明可用作荧光探针的用于长期生物成像的惰性生物相容性荧光纳米材料。最后，讨论了一些正在为生物成像应用而不断发展的用于短期生物成像的生物相容性和可生物降解的纳米材料。总之，这些进展标志着在生物医学成像中朝着可持续性和功能性迈出了变革性的一步。
