Department of Reproductive Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore.
Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Nutrients. 2023 Dec 31;16(1):146. doi: 10.3390/nu16010146.
The impact of vitamin D supplementation on 25-hydroxyvitamin D (25OHD) levels, metabolic status, and pregnancy outcomes in pregnant women with overweight and obesity (OW/OB) is uncertain. This study aimed to examine whether administrating 800 IU of vitamin D3 orally would improve maternal serum 25OHD levels, lipid profile, and pregnancy outcomes compared to 400 IU. This was a two-arm, parallel, non-blinded randomised controlled trial involving 274 pregnant women recruited from KK Women's and Children's Hospital, with a body mass index of ≥25 kg/m within 16 weeks gestation. The participants were randomly assigned to receive 800 IU/day (intervention group) or 400 IU/day (control group) of oral vitamin D3 supplements. The primary outcomes were maternal serum 25OHD and lipid levels at 24-28 weeks gestation. The secondary outcomes included maternal and birth outcomes. Compared with controls ( 119), the intervention group ( 112) exhibited higher 25OHD levels at 24-28 weeks gestation (adjusted mean difference 6.52 nmol/L; 95% confidence interval 2.74, 10.31). More women in the intervention group achieved sufficient 25OHD levels (77.7% vs. 55.5%; < 0.001). No differences were observed in lipid profiles or maternal or birth outcomes between the groups. An additional 400 IU of oral vitamin D3 supplementation increased serum 25OHD levels but did not impact lipid profiles or pregnancy outcomes.
在超重和肥胖（OW/OB）孕妇中，补充维生素 D 对 25-羟维生素 D（25OHD）水平、代谢状态和妊娠结局的影响尚不确定。本研究旨在观察与每天补充 400IU 相比，每天口服 800IU 维生素 D3 是否能改善母体血清 25OHD 水平、血脂谱和妊娠结局。这是一项在 KK 妇女儿童医院招募的 274 名妊娠 16 周内 BMI≥25kg/m2 的孕妇进行的两臂、平行、非盲随机对照试验。参与者被随机分配接受每天 800IU（干预组）或 400IU（对照组）的口服维生素 D3 补充剂。主要结局是 24-28 周妊娠时的母体血清 25OHD 和血脂水平。次要结局包括母体和分娩结局。与对照组（119 例）相比，干预组（112 例）在 24-28 周妊娠时血清 25OHD 水平更高（调整平均差异 6.52nmol/L；95%置信区间 2.74，10.31）。干预组有更多的妇女达到足够的 25OHD 水平（77.7% vs. 55.5%；<0.001）。两组间血脂谱或母体或分娩结局无差异。额外补充 400IU 口服维生素 D3 可增加血清 25OHD 水平，但不影响血脂谱或妊娠结局。
