Neonatal Intensive and Special Care, The Royal Women's Hospital, Parkville, Victoria, Australia; Newborn Intensive Care Unit, The Mercy Hospital for Women, Heidelberg, Victoria, Australia.
Neonatal Intensive and Special Care, The Royal Women's Hospital, Parkville, Victoria, Australia.
J Pediatr. 2014 Apr;164(4):726-9. doi: 10.1016/j.jpeds.2013.10.087. Epub 2013 Dec 15.
To assess the effects of different nasal continuous positive airway pressure (nCPAP) pressures on cardiac performance in preterm infants with minimal lung disease, we conducted a randomized, blinded crossover study.
We studied infants between 28 and 34 weeks' corrected gestational age, treated with nCPAP of 5 cm H2O, in air. Infants with significant cardiac shunts were excluded. Infants were randomly assigned to nCPAP levels of 4, 6, and 8 cm H2O for 15 minutes each. Right and left ventricular outputs and left pulmonary artery and superior vena cava flows were measured 15 minutes after each change.
Thirty-four infants born at a mean gestational age of 29 weeks with a birth weight of 1.3 kg were studied. There were no significant differences in right and left ventricular outputs and left pulmonary artery and superior vena cava flows at different levels of nCPAP.
We investigated the effect of increasing nCPAP levels on cardiac output. We conclude that nCPAP levels between 4 and 8 cm H2O did not have an effect on cardiac output in stable preterm infants with minimal lung disease.
评估不同持续气道正压通气（nCPAP）压力对最小肺疾病早产儿心脏功能的影响，我们进行了一项随机、双盲交叉研究。
我们研究了胎龄校正后 28 至 34 周、接受空气 nCPAP 5cmH2O 治疗的婴儿。排除有明显心脏分流的婴儿。婴儿随机分配到 nCPAP 4、6 和 8cmH2O 水平，每个水平持续 15 分钟。每次改变后 15 分钟测量右心室和左心室输出以及左肺动脉和上腔静脉流量。
34 名胎龄平均为 29 周、体重 1.3kg 的婴儿接受了研究。在不同 nCPAP 水平下，右心室和左心室输出以及左肺动脉和上腔静脉流量没有显著差异。
我们研究了增加 nCPAP 水平对心输出量的影响。我们的结论是，在最小肺疾病的稳定早产儿中，nCPAP 水平在 4 至 8cmH2O 之间对心输出量没有影响。
