Zhou X L, Liu J C
Nanchang University, The First Affiliated Hospital, Department of Cardiac Surgery, Donghu DistrictNanchangJiangxi, China, Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Donghu District, Nanchang, Jiangxi, China.
Braz J Med Biol Res. 2014 Jan;47(1):1-10. doi: 10.1590/1414-431X20133177. Epub 2013 Dec 12.
Notch signaling is an evolutionarily ancient, highly conserved pathway important for deciding cell fate, cellular development, differentiation, proliferation, apoptosis, adhesion, and epithelial-to-mesenchymal transition. Notch signaling is also critical in mammalian cardiogenesis, as mutations in this signaling pathway are linked to human congenital heart disease. Furthermore, Notch signaling can repair myocardial injury by promoting myocardial regeneration, protecting ischemic myocardium, inducing angiogenesis, and negatively regulating cardiac fibroblast-myofibroblast transformation. This review provides an update on the known roles of Notch signaling in the mammalian heart. The goal is to assist in developing strategies to influence Notch signaling and optimize myocardial injury repair.
Notch信号通路是一条在进化上古老且高度保守的信号通路，对决定细胞命运、细胞发育、分化、增殖、凋亡、黏附以及上皮-间质转化起着重要作用。Notch信号通路在哺乳动物心脏发生过程中也至关重要，因为该信号通路中的突变与人类先天性心脏病相关。此外，Notch信号通路可通过促进心肌再生、保护缺血心肌、诱导血管生成以及负向调节心脏成纤维细胞向肌成纤维细胞的转化来修复心肌损伤。本综述对Notch信号通路在哺乳动物心脏中的已知作用进行了更新。目的是协助制定影响Notch信号通路的策略并优化心肌损伤修复。
