Department of Orthopaedics and Traumatology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium,
Int Orthop. 2014 Feb;38(2):235-41. doi: 10.1007/s00264-013-2231-8. Epub 2013 Dec 18.
A study was conducted to compare minimum 15-year survivorship and outcome of the Genesis I and II implants for total knee arthroplasty (TKA).
We retrospectively reviewed 245 consecutive TKA implanted between January 1995 and October 1997. Genesis I was implanted in 156 knees and Genesis II in 89 knees.
At 15-17 years, 75 patients (31%) had died, 28 patients (11%) were lost to follow-up and 11 TKA were revised (4.6%), including ten Genesis I (6.4%) and one Genesis II (1.1%); 131 TKA (53%) were available for follow-up. Cumulative survivorship was 92.4% at 15.7 years. Survival in patients <69 years at surgery was lower (88.0%) compared with patients ≥69 years (98.5%; p = 0.023). In patients <69 years, Genesis I survival (84.3%) was worse compared with Genesis II (97.1%) (p = 0.018). Polyethylene (PE) Insert thickness ≤11 mm had significantly better survivorship (97.1%) compared with PE >11 mm (56.7%) (p < 0.0001) CONCLUSIONS: At a minimum of 15 years, the overall (92.4%) survivorship of Genesis TKA was good, with excellent (98.1%) survivorship of the Genesis II design. Revision rates were higher with Genesis I in the younger age group and with insert thickness >11 mm, possibly due to longer shelf life of less frequently used sizes.
本研究旨在比较 Genesis I 和 II 型全膝关节置换（TKA）植入物的最低 15 年生存率和结果。
我们回顾性分析了 1995 年 1 月至 1997 年 10 月期间连续 245 例 TKA 植入患者。其中，Genesis I 型植入 156 例，Genesis II 型植入 89 例。
15-17 年时，75 例（31%）患者死亡，28 例（11%）失访，11 例 TKA 翻修（4.6%），包括 10 例 Genesis I（6.4%）和 1 例 Genesis II（1.1%）；131 例 TKA（53%）可进行随访。15.7 年时累积生存率为 92.4%。手术时年龄<69 岁的患者生存率较低（88.0%），而年龄≥69 岁的患者生存率较高（98.5%；p=0.023）。在年龄<69 岁的患者中，Genesis I 生存率（84.3%）低于 Genesis II（97.1%）（p=0.018）。聚乙烯（PE）插入物厚度≤11mm 的生存率明显更好（97.1%），而厚度>11mm 的生存率较差（56.7%）（p<0.0001）。
至少 15 年时，Genesis TKA 的总体（92.4%）生存率良好，Genesis II 设计的生存率极佳（98.1%）。在年轻患者组和插入物厚度>11mm 的患者中，Genesis I 的翻修率更高，可能是由于较少使用的尺寸货架寿命更长。
