Jiang Jun, Quan Xun-Feng, Zhang Li, Wang Yi-Chun
Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Asian Pac J Cancer Prev. 2013;14(5):3169-73. doi: 10.7314/apjcp.2013.14.5.3169.
Findings from previous published studies regarding the association of the XRCC3 Thr241Met polymorphism with glioma susceptibility have often been conflicting. Therefore, a meta-analysis including all available publications was carried out to make a more precise estimation of the potential relationship.
By searching the electronic databases of Pubmed and Embase (up to April 1st, 2013), a total of nine case-control studies with 3,752 cases and 4,849 controls could be identified for inclusion in the current meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of the association.
This meta-analysis showed the XRCC3 Thr241Met polymorphism to be significantly associated with decreased glioma risk in the allelic model (Met allele vs. Thr allele: OR= 0.708, 95%CI= 0.631-0.795). Moreover, we also observed a statistically significant association between the XRCC3 Thr241Met polymorphism and reduced glioma risk in analyses stratified by ethnicity (Asian) and source of controls (hospital based) in the allelic model.
Current evidence suggests that the XRCC3 Thr241Met polymorphism may be a risk factor for glioma development, especially in Asians.
先前发表的关于XRCC3基因Thr241Met多态性与胶质瘤易感性关联的研究结果常常相互矛盾。因此，开展了一项纳入所有可用出版物的荟萃分析，以更精确地评估潜在关系。
通过检索Pubmed和Embase电子数据库（截至2013年4月1日），共确定了9项病例对照研究，包括3752例病例和4849例对照，纳入当前的荟萃分析。计算比值比（OR）及95%置信区间（CI），以评估关联强度。
该荟萃分析表明，在等位基因模型中，XRCC3基因Thr241Met多态性与胶质瘤风险降低显著相关（Met等位基因与Thr等位基因相比：OR = 0.708，95%CI = 0.631 - 0.795）。此外，在等位基因模型中，按种族（亚洲人）和对照来源（基于医院）分层分析时，我们还观察到XRCC3基因Thr241Met多态性与胶质瘤风险降低之间存在统计学显著关联。
当前证据表明，XRCC3基因Thr241Met多态性可能是胶质瘤发生的一个风险因素，尤其是在亚洲人中。
